The heart transplantation is a technique in which the failing heart is being replaced by another heart which is taken from a suitable donor. Heart transplantation is the only choice to treat a patient at the final stage of congestive heart failure. Heart transplantation helps improving the life quality for the recipients. Though heart transplantation is a life-saving method, it involves many risks. Careful monitoring, medical care and treatment can prevent the risks. The complications after a heart transplantation surgery includes infection and organ rejection.